Pizotifen Malate

CAS No. 5189-11-7

Pizotifen Malate( —— )

Catalog No. M14815 CAS No. 5189-11-7

Pizotifen malate is a highly selective 5-HT receptor blocking agent, which is a benzocycloheptane based drug.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Pizotifen Malate
  • Note
    Research use only, not for human use.
  • Brief Description
    Pizotifen malate is a highly selective 5-HT receptor blocking agent, which is a benzocycloheptane based drug.
  • Description
    Pizotifen malate is a highly selective 5-HT receptor blocking agent, which is a benzocycloheptane based drug.
  • In Vitro
    Pizotifen malate (BC-105 malate)is a potent 5-HT2 receptor antagonist, with a high affinity for 5-HT1C binding site. Pizotifen is an antidepresent 5-HT2A receptor antagonist and has the capacity to inhibit serotonin-enhanced ADP-induced platelet aggregation.
  • In Vivo
    The weights of the fetuses are significantly reduced by all administered doses of Pipethiadene and Pizotifen malate (BC-105 malate) ; the weights of the placentas are significantly reduced after 0.6 and 1.2 mg/kg Pipethiadene and only after the middle dose of Pizotifen malate. The means of the implantations, live, dead fetuses, resorptions and the occurrence of external, skeletal and visceral anomalies do not differ from the control group. The number of chromosome aberrations in the bone marrow cells of treated mice does not differ significantly from the negative control group. The micronucleus test reveals no elevation in the frequency of micronuclei as compared to the control group. After the two higher doses of both Pipethiadene and Pizotifen maleate, the mitotic indices are lower than in the control group.
  • Synonyms
    ——
  • Pathway
    Endocrinology/Hormones
  • Target
    5-HT Receptor
  • Recptor
    5-HT
  • Research Area
    Neurological Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    5189-11-7
  • Formula Weight
    429.53
  • Molecular Formula
    C19H21NS·C4H6O5
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 21 mg/mL (48.89 mM)
  • SMILES
    OC(=O)C=CC(O)=O.CN1CCC(CC1)=C1C2=C(CCC3=CC=CC=C13)SC=C2
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Margarit MV, et al. Drug Dev Ind Pharm. 2001 Jul;27(6):517-22.
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