
Pizotifen Malate
CAS No. 5189-11-7
Pizotifen Malate( —— )
Catalog No. M14815 CAS No. 5189-11-7
Pizotifen malate is a highly selective 5-HT receptor blocking agent, which is a benzocycloheptane based drug.
Purity : >98% (HPLC)






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Biological Information
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Product NamePizotifen Malate
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NoteResearch use only, not for human use.
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Brief DescriptionPizotifen malate is a highly selective 5-HT receptor blocking agent, which is a benzocycloheptane based drug.
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DescriptionPizotifen malate is a highly selective 5-HT receptor blocking agent, which is a benzocycloheptane based drug.
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In VitroPizotifen malate (BC-105 malate)is a potent 5-HT2 receptor antagonist, with a high affinity for 5-HT1C binding site. Pizotifen is an antidepresent 5-HT2A receptor antagonist and has the capacity to inhibit serotonin-enhanced ADP-induced platelet aggregation.
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In VivoThe weights of the fetuses are significantly reduced by all administered doses of Pipethiadene and Pizotifen malate (BC-105 malate) ; the weights of the placentas are significantly reduced after 0.6 and 1.2 mg/kg Pipethiadene and only after the middle dose of Pizotifen malate. The means of the implantations, live, dead fetuses, resorptions and the occurrence of external, skeletal and visceral anomalies do not differ from the control group. The number of chromosome aberrations in the bone marrow cells of treated mice does not differ significantly from the negative control group. The micronucleus test reveals no elevation in the frequency of micronuclei as compared to the control group. After the two higher doses of both Pipethiadene and Pizotifen maleate, the mitotic indices are lower than in the control group.
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Synonyms——
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PathwayEndocrinology/Hormones
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Target5-HT Receptor
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Recptor5-HT
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Research AreaNeurological Disease
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Indication——
Chemical Information
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CAS Number5189-11-7
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Formula Weight429.53
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Molecular FormulaC19H21NS·C4H6O5
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Purity>98% (HPLC)
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SolubilityDMSO: 21 mg/mL (48.89 mM)
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SMILESOC(=O)C=CC(O)=O.CN1CCC(CC1)=C1C2=C(CCC3=CC=CC=C13)SC=C2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Margarit MV, et al. Drug Dev Ind Pharm. 2001 Jul;27(6):517-22.
molnova catalog



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